For enhanced safety, the front and second-row seat shoulder belts of the Lexus TX have pretensioners to tighten the seatbelts and eliminate dangerous slack in the event of a collision and force limiters to limit the pressure the belts will exert on the passengers. The Chrysler Pacifica doesn’t offer pretensioners for its second-row seat belts.
The TX has a standard Secondary Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Pacifica doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
When descending a steep, off-road slope, the TX AWD’s standard Downhill Assist allows you to creep down safely. The Pacifica doesn’t offer Downhill Assist.
Both the TX and Pacifica have rear cross-traffic warning, but the TX Premium/Luxury has Parking Support Brake (automatically applies the brakes) to better prevent a collision when backing near traffic. The Pacifica’s Rear Cross Path Detection doesn’t automatically brake.
The TX’s driver alert monitor detects an inattentive driver then sounds a warning and suggests a break. According to the NHTSA, drivers who fall asleep cause about 100,000 crashes and 1500 deaths a year. The Pacifica doesn’t offer a driver alert monitor.
Both the TX and the Pacifica have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front wheel drive, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, available all wheel drive and around view monitors.
Side impacts caused 23% of all road fatalities in 2018, down from 29% in 2003, when the Insurance Institute for Highway Safety introduced its side barrier test. In order to continue improving vehicle safety, the IIHS has started using a more severe side impact test: 37 MPH (up from 31 MPH), with a 4180-pound barrier (up from 3300 pounds). The results of this newly developed test demonstrates that the Lexus TX is safer than the Pacifica:
| 
 | TX | Pacifica | 
| Overall Evaluation | GOOD | ACCEPTABLE | 
| Structure | GOOD | GOOD | 
| 
 | Driver Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Head Injury Criterion | 38 | 167 | 
| Neck Tension | 134 lbs. | 335 lbs. | 
| Torso | GOOD | GOOD | 
| Shoulder Deflection | .35 in | .94 in | 
| Shoulder Force | 156 lbs. | 223 lbs. | 
| Torso Max Deflection | 1.1 in | 1.26 in | 
| Torso Deflection Rate | 4 MPH | 5 MPH | 
| Head Protection | GOOD | GOOD | 
| 
 | Passenger Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Neck Tension | 67 lbs. | 112 lbs. | 
| Torso | GOOD | ACCEPTABLE | 
| Shoulder Deflection | .67 in | 1.1 in | 
| Shoulder Force | 245 lbs. | 424 lbs. | 
| Torso Max Deflection | 1.1 in | 1.97 in | 
| Torso Deflection Rate | 6 MPH | 12 MPH | 
| Pelvis | GOOD | POOR | 
| Pelvis Force | 446 lbs. | 1450 lbs. | 
| Head Protection | GOOD | GOOD | 

