The TX has a standard Secondary Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The QX60 doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
Both the TX and QX60 have rear cross-traffic warning, but the TX Premium/Luxury has Parking Support Brake (automatically applies the brakes) to better prevent a collision when backing near traffic. The QX60’s Rear Cross Traffic Alert doesn’t automatically brake.
Both the TX and the QX60 have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, front wheel drive, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, available all wheel drive and around view monitors.
Side impacts caused 23% of all road fatalities in 2018, down from 29% in 2003, when the Insurance Institute for Highway Safety introduced its side barrier test. In order to continue improving vehicle safety, the IIHS has started using a more severe side impact test: 37 MPH (up from 31 MPH), with a 4180-pound barrier (up from 3300 pounds). The results of this newly developed test demonstrates that the Lexus TX is safer than the QX60:
| 
 | TX | QX60 | 
| Overall Evaluation | GOOD | GOOD | 
| Structure | GOOD | ACCEPTABLE | 
| 
 | Driver Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Head Injury Criterion | 38 | 125 | 
| Neck Tension | 134 lbs. | 268 lbs. | 
| Torso | GOOD | GOOD | 
| Shoulder Deflection | .35 in | .63 in | 
| Torso Deflection Rate | 4 MPH | 5 MPH | 
| Pelvis | ACCEPTABLE | MARGINAL | 
| Pelvis Force | 1049 lbs. | 1160 lbs. | 
| Head Protection | GOOD | GOOD | 
| 
 | Passenger Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Neck Tension | 67 lbs. | 89 lbs. | 
| Torso | GOOD | GOOD | 
| Pelvis | GOOD | GOOD | 
| Pelvis Force | 446 lbs. | 580 lbs. | 
| Head Protection | GOOD | GOOD | 

