The LX has a standard Secondary Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The MDX doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the LX. But it costs extra on the MDX.
When descending a steep, off-road slope, the LX’s standard CRAWL Control allows you to creep down safely. The MDX doesn’t offer CRAWL Control.
Both the LX and MDX have rear cross-traffic warning, but the LX has Parking Support Brake (automatically applies the brakes) to better prevent a collision when backing near traffic. The MDX’s Rear Cross Traffic Monitor doesn’t automatically brake.
Both the LX and the MDX have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.
The Lexus LX weighs 867 to 1674 pounds more than the Acura MDX. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

